Tag Archives: HLTH

Breaking News: Sinaptica's Noninvasive Neuromodulation Device Slows Alzheimer’s Disease in Year-Long Trial

Breaking News: Sinaptica’s Noninvasive Neuromodulation Device Slows Alzheimer’s Disease in Year-Long Trial



Hear the latest groundbreaking news in Alzheimer’s research. Sinaptica, a member of StartUp Health’s Alzheimer’s Moonshot Community, has announced significant results from its Phase 2 clinical trial testing the company’s noninvasive, personalized, precise neuromodulation designed to stop the progression of Alzheimer’s disease.

Ken Mariash, CEO of Sinaptica, joined us in the StartUp Health Studio to break it all down for us. As you’ll hear, the interview took place prior to the release of this data, which became public on October 31.

In this exclusive interview, you’ll learn:

  • Details on Sinaptica’s Phase 2 trial results show significant promise in slowing Alzheimer’s progression
  • The science behind Sinaptica’s technology
  • How personalized neuromodulation is revolutionizing brain health
  • The potential for proactive brain strengthening and repair
  • The impact on patients’ daily lives
  • The future of Alzheimer’s treatment

This episode is a must-listen for anyone interested in Alzheimer’s research, neuroscience, and the power of innovation to transform lives.


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These Founders Are Pairing AI + SDoH to Re-humanize Healthcare



Our episode this week was recorded during our StartUp Health Studio interviews at the recent HLTH conference in Las Vegas. At the event, a hot topic was how artificial intelligence, specifically generative AI, is going to fundamentally shift healthcare delivery. AI can help us comb through mountains of information and take action on data points that were previously hidden from view. But many people have a serious concern – even a fear – that AI will degrade the doctor-patient relationship and effectively dehumanize healthcare.

Our two guests today both joined the StartUp Health community earlier in 2023. They are pushing back against that narrative and suggesting with their companies that AI and big data can be leveraged to re-humanize healthcare delivery.

First we’ll talk with Nicole Cook, the CEO & Founder of Alvee, who is on a health moonshot mission to use AI-driven solutions to promote health equity and improve health outcomes for all. Cook reminds us that doctors are spending an inordinate amount of their time with a patient tapping away at a screen. The status quo is not working, so can new patient data tools help? Can they bring the right information to the surface at the right time and the right way, so healthcare providers can get back to making eye contact with patients?

What’s Cook is building at Alvee is resonating, as she went on to win the HLTH Startup Pitch Competition.

Next, we hear from Chris Turner, CEO & Co-founder at HealthBook+, who is attempting to create a fuller, more human picture of each patient using all available data including data from some nontraditional sources. HealthBook+ provides a simple-to-use, digital-first care platform which consolidates health data and keeps it private, as well as predicts conditions and recommends the next best health actions.

If the top line story for this episode is how data and AI could be used to create a more human electronic health record, the secondary story is about who can benefit from this technology.

Everyone’s talking about social determinants of health. This idea that we need to address the non-medical drivers of health, like access to fresh food and transportation. Healthcare providers care about these issues but don’t have the time or resources to analyze the data. That’s where Alvee Health and HealthBook+ can come in. Providing a fuller, more human analysis of patient data means taking into account important barriers to care and getting smart about how to overcome them.

So let’s get into it.


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Looking to break down health barriers? If you’re an entrepreneur or investor, contact us to learn how you can join our Health Equity Moonshot.
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Is Value-Based Care Finally at a Tipping Point? Cityblock and Enlace Health Share Thoughts from StartUp Health @ HLTH



Welcome to StartUp Health NOW, the podcast where we celebrate the entrepreneurs and innovators transforming the future of health.

Value-based care has the dubious distinction of being the oldest new idea in health innovation. For decades we’ve talked about the benefits of creating medical payment structures that tie compensation to the patient’s outcome, rather than simply paying for services. It’s pretty clear that if a hospital makes its money off of performing certain tests or procedures, it’s going to have a bias – whether overt or subconscious – towards doing more of those tests and procedures. There’s no financial incentive to give the patient a lower-cost option that’s just as effective.

The alternative to America’s “fee for service” model is one where financial risk is shared by multiple entities, and pricing is bundled in a transparent way. This so-called value-based structure does away with surprise bills, and makes sure that doctors and hospitals are financially incentivized to keep patients healthy. Of course, that’s an oversimplification, and we could have a whole other episode about the role of fee-for-service medicine, but that’s not our subject for today.

Today, we’re getting a look at how value-based healthcare companies are faring through the lens of two StartUp Health companies, Cityblock Health and Enlace Health.

Recently, StartUp Health brought together nearly 100 of our portfolio companies at HLTH in Las Vegas, and while on the show floor, we caught up with some of our top founders in the StartUp Health Studio. That included Bill Nordmark, CEO of Enlace Health, which last year raised a $60M series D, and Dr. Kameron Matthews, Chief Health Officer at Cityblock Health, which is now valued at more than a billion dollars. Both of these companies are making value-based care business models a reality. For Enlace, it’s about building a new infrastructure that allows other companies to operate successfully within a new financial model. For Cityblock, it’s about deploying value-based care at scale in a way that addresses the needs of vulnerable populations.

Listen in for Logan Plaster’s chats with Bill Nordmark and Dr. Kameron Matthews, held in the busy StartUp Health Pavilion at HLTH in Las Vegas.


Learn more and connect with Health Transformers.

Entrepreneurs: How to get investment from StartUp Health startuphealth.com

Investors: Contact us to learn how to invest in Health Moonshots
Want more content like this? You can subscribe to the podcast as well as other health innovation updates at startuphealth.com/content.
Sign up for StartUp Health Insider™ to get funding insights, news, and special updates delivered to your inbox.

Passionate about Type 1 diabetes? If you’re an entrepreneur or investor, contact us to learn how you can join our T1D Moonshot.
Looking to break down health barriers? If you’re an entrepreneur or investor, contact us to learn how you can join our Health Equity Moonshot.

A Candid Conversation w/ Glen Tullman and Lee Shapiro, Investors in the StartUp Health Moonshots Impact Fund



Join us in Miami Beach in March for StartUp Health @ ViVE 2022: startuphealth.com/vive

This week on the show we’re revisiting a conversation that first aired in 2021. It’s from a fireside chat we had with Lee Shapiro and Glen Tullman, the dynamic duo behind ventures like Allscripts, 7wire Ventures, and Livongo. On the call, the two talk with Steven Krein, StartUp Health CEO & Co-founder, about 25 years of lessons learned in investing and how they built health moonshot companies. We hear how Transcarent was “Hatched” and the success drivers behind Livongo. More importantly, we get a candid view of how two icons of health investors think about work and life.

We also learn a bit about why both Lee Shapiro and Glen Tullman have invested in the StartUp Health Moonshots Impact Fund, which launched last year. This fund makes it easy for investors to back a diverse portfolio of health startups, and you can learn all about it at healthmoonshots.com.

Lee Shapiro and Glen Tullman will be joining StartUp Health and more than 50 of our Health Transformers at ViVE, a premier health innovation event by HLTH and CHIME that’s happening in Miami Beach from March 6-9. StartUp Health @ ViVE will bring together founders, partners, and investors under one collaborative roof, and we’ll be broadcasting stories of health moonshot progress from the StartUp Health TV Studio. We hope you’ll join us in Miami Beach! Learn more and save on your ViVE registration at startuphealth.com/vive.

Entrepreneurs: How to get investment from StartUp Health startuphealth.com

Investors: How to invest in StartUp Health Moonshots healthmoonshots.com
Want more content like this? You can subscribe to the podcast as well as other health innovation updates at startuphealth.com/content.
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How HLTH and StartUp Health Are Uniting the Health Innovation Ecosystem, with Rich Scarfo



On January 18, 2022, StartUp Health announced a multi-year partnership with HLTH, the leading platform for bringing together the health ecosystem around innovation, entrepreneurship, and technology. In order to understand more about the partnership, we sat down with Rich Scarfo, President of HLTH. In addition to hearing his take on the recent news, we get to hear some war stories about what it has been like to be in the event business during COVID-19, and how HLTH thrived in the face of some daunting challenges.

Join us in Miami Beach in March for StartUp Health @ ViVE 2022: startuphealth.com/vive

Entrepreneurs: How to get investment from StartUp Health startuphealth.com

Investors: How to invest in StartUp Health Moonshots healthmoonshots.com
Want more content like this? You can subscribe to the podcast as well as other health innovation updates at startuphealth.com/content.
Sign up for StartUp Health Insider™ to get funding insights, news, and special updates delivered to your inbox.


Curatio’s CEO and Chief Growth Officer Share How Their Platform is Filling a Social Care Gap for Chronic Disease Patients



Logan Plaster, StartUp Health’s Media Director and Editor-in-Chief of the StartUp Health magazine, caught up with Curatio’s CEO and Founder, Lynda Brown-Ganzert and Chief Growth Officer, Jeff Wandzura at the 2019 HLTH conference in Las Vegas. Curatio is described as the “worlds first social health prescription.” In this episode of StartUp Health:NOW, Lynda and Jeff give a walk-through of their health platform and discuss how they are helping patients better understand their condition by providing them with a support community and the tools needed to take control of their own health.

Location: HLTH 2019 Las Vegas, NV

Entrepreneurs: How to get investment from StartUp Health https://www.startuphealth.com/
Investors: How to invest in StartUp Health Moonshots http://www.healthmoonshots.com

Want more content like this? You can subscribe to the podcast as well as other health innovation updates at startuphealth.com/content. Sign up for StartUp Health Insider™ to get funding insights, news, and special updates delivered to your inbox.